HuT 102Homo sapiens (Human)Cancer cell line
Also known as: NCI-H102, HUT102, Hut102, HuT102, HUT-102, Hut-102, HuT-102, Hut 102, HUT 102
HUT 102
Quick Overview
Human T-cell line with HTLV-1 infection, used in leukemia and lymphoma research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_3526 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 28 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | black_or_african_american |
Disease Information
| Disease | Classic mycosis fungoides |
|---|---|
| Lineage | Lymphoid |
| Subtype | Mycosis Fungoides |
| OncoTree Code | MYCF |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000612_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
TAS-116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T-cell leukemia.
Morishita K.
Cancer Sci. 113:684-696(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
STR profiling of HTLV-1-infected cell lines.";
Raimondi V., Minuzzo S.A., Ciminale V., D'Agostino D.M.
Methods Mol. Biol. 1582:143-154(2017).
The discovery of HTLV-1, the first pathogenic human retrovirus.";
Coffin J.M.
Proc. Natl. Acad. Sci. U.S.A. 112:15525-15529(2015).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
J. Virol. 89:713-729(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Hasegawa H., Yamada Y.
Eur. J. Haematol. 82:301-307(2009).
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Langerak A.W.
Leukemia 21:230-237(2007).
Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.
Kamihira S.
Br. J. Haematol. 128:253-265(2005).
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.
Shimozato O., Taylor G.P., Bangham C.R.M., Derse D.D.
Blood 102:4130-4136(2003).
PTEN gene alterations in lymphoid neoplasms.";
Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.
Blood 92:3410-3415(1998).
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Aizawa Y., Ueda R., Seto M.
Jpn. J. Cancer Res. 89:712-718(1998).
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Liu C., Kondo E., Minowada J., Akagi T.
Jpn. J. Cancer Res. 87:1070-1077(1996).
NCI-Navy Medical Oncology Branch cell line data base.";
Carney D.N., Minna J.D., Mulshine J.L.
J. Cell. Biochem. Suppl. 24:32-91(1996).
T-cell lymphoma cell lines (HUT102 and HUT78) established at the National Cancer Institute: history and importance to understanding the biology, clinical features, and therapy of cutaneous T-cell lymphomas (CTCL) and adult T-cell leukemia-lymphomas (ATLL).
Bunn P.A. Jr., Foss F.M.
J. Cell. Biochem. Suppl. 24:12-23(1996).
NCI series of cell lines: an historical perspective.";
Gazdar A.F., Minna J.D.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996).
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Einhorn S.
Eur. J. Haematol. 56:313-318(1996).
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Uppenkamp M.J., Nowrousian M.R., Seeber S., Opalka B.
Br. J. Haematol. 91:350-354(1995).
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.
Hattori T., Yamabe H., Okuma M., Uchiyama T.
Blood 86:2350-2357(1995).
Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor.
Gootenberg J.E., Ruscetti F.W., Mier J.W., Gazdar A.F., Gallo R.C.
J. Exp. Med. 154:1403-1418(1981).
Differential expression of the amv gene in human hematopoietic cells.
Aaronson S.A., Wong-Staal F.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukaemia.
Poiesz B.J., Ruscetti F.W., Reitz M.S. Jr., Kalyanaraman V.S., Gallo R.C.
Nature 294:268-271(1981).
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.
Gallo R.C.
Proc. Natl. Acad. Sci. U.S.A. 77:7415-7419(1980).
Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas.
Schechter G.P., Guccion J.G.
Blood 55:409-417(1980).
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:537-548(1985).
Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:549-559(1985).
p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.
Yoshida M.
Proc. Natl. Acad. Sci. U.S.A. 82:8359-8363(1985).
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:209-229(1985).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
Anecdotal Information
- This is the cell line that was used by Gallo's lab to isolate HTLV-1 (PubMed=26696625)