SW579Homo sapiens (Human)Cancer cell line

Also known as: SW 579, SW-579

🤖 AI SummaryBased on 8 publications

Quick Overview

SW579 is a human tumor cell line derived from a thyroid carcinoma, used in cancer research for studying tumor biology and drug ...

Detailed Summary

SW579 is a human tumor cell line established from a thyroid carcinoma, widely used in cancer research for investigating tumor biology, drug sensitivity, and molecular mechanisms. It has been utilized in studies related to cancer cell line characterization, genetic diversity, and therapeutic response. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genetic and molecular profiles to support research on cancer treatment and precision medicine. SW579 is also noted for its role in studies involving HLA typing, neo-epitope prediction, and virus detection, contributing to understanding cancer immunology and tumor heterogeneity.

Research Applications

Cancer ResearchDrug Sensitivity StudiesGenetic and Molecular ProfilingImmunology and Tumor BiologyPrecision Medicine

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used in HLA typing and neo-epitope predictionUtilized for virus detection in cancer cell linesCharacterized for genetic diversity and tumor heterogeneity

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3603
Species	Homo sapiens (Human)
Tissue Source	Thyroid gland[UBERON:UBERON_0002046]

Donor Information

Age	59
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Thyroid carcinoma
Lineage	Head and Neck
Subtype	Head and Neck Squamous Cell Carcinoma
OncoTree Code	HNSC

DepMap Information

Source Type	ATCC
Source ID	ACH-000163_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ile255Ser (c.764T>G)	Homozygous	-	Unknown, PubMed=1516062
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

15,17,18

D19S433

13,14

D21S11

29,31

D2S1338

17,18

D3S1358

15,18

D5S818

D7S820

8,9

D8S1179

11,13

FGA

21,24

Penta D

9,12

Penta E

11,12

TH01

8,9.3

TPOX

8,10

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Targeted treatment options of recurrent radioactive iodine refractory Hurthle cell cancer.

Solleveld-Westerink N., van Wezel T., Kapiteijn E.H.W., Morreau H.

Cancers (Basel) 11:1185.1-1185.16(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

ROS-induced near-homozygous genomes in thyroid cancer.";

van Wezel T., Morreau H.

Endocr. Relat. Cancer 25:83-97(2018).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Polymorphic enzyme analysis of cultured human tumor cell lines.";

Dracopoli N.C., Fogh J.

J. Natl. Cancer Inst. 70:469-476(1983).

PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.

Yoshimoto K., Iwahana H., Fukuda A., Sano T., Saito S., Itakura M.

Cancer Res. 52:5061-5064(1992).

PubMed

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

DOI PubMed

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

DOI PubMed

Head and neck tumor cell lines.";

Carey T.E.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).

DOI