T1-73Homo sapiens (Human)Undefined cell line type
Also known as: T173, TI-73
🤖 AI SummaryBased on 5 publications
Quick Overview
Human fibroblast cell line for cancer research and drug sensitivity studies.
Detailed Summary
The T1-73 cell line is a human fibroblast cell line derived from an unspecified tissue and disease origin. It is utilized in cancer research, particularly in studies related to drug sensitivity and predictive modeling of anticancer drug responses. This cell line is part of the Cancer Cell Line Encyclopedia (CCLE), which provides comprehensive genomic and pharmacological data for 947 cancer cell lines. The CCLE project aims to identify genetic, lineage, and gene-expression-based predictors of drug sensitivity, facilitating the development of personalized cancer therapies. T1-73 is used in research to understand the molecular mechanisms of cancer and to test the efficacy of various anticancer compounds. Its role in the CCLE highlights its importance in advancing cancer research through large-scale genomic and pharmacological profiling.
Research Applications
Cancer researchDrug sensitivity studiesPredictive modeling of anticancer drug responsesGenomic and pharmacological profiling
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used for identifying drug sensitivity predictorsUtilized in large-scale genomic and pharmacological studies
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3605 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone[UBERON:UBERON_0002481] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Non-Cancerous |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000529_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
11,12
D16S539
12
D18S51
13,14
D19S433
12,15
D21S11
30,31.2
D2S1338
17,24
D3S1358
17,19
D5S818
8,12
D7S820
8,10
D8S1179
12,14
FGA
19,24
Penta D
9,14
Penta E
9,12
TH01
9,9.3
TPOX
8,9
vWA
15,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Fibroblasts cell lines misclassified as cancer cell lines.";
de Weck A., Bitter H., Kauffmann A.
bioRxiv 2017:166199-166199(2017).