TOV-21GHomo sapiens (Human)Cancer cell line
Also known as: TOV21, TOV21G, TOV-21g
Quick Overview
TOV-21G is a human ovarian cancer cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_3613 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ovary[UBERON:UBERON_0000992] |
Donor Information
| Age | 62 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Clear cell adenocarcinoma of the ovary |
|---|---|
| Lineage | Ovary/Fallopian Tube |
| Subtype | Clear Cell Ovarian Cancer |
| OncoTree Code | CCOV |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000885_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | PTEN | p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA) | Heterozygous | - | Unknown, Unknown, PubMed=25230021 |
| MutationSimple | PIK3CA | p.His1047Tyr (c.3139C>T) | Heterozygous | - | Unknown, Unknown, PubMed=28273451, PubMed=25230021, PubMed=24224046, PubMed=22705003 |
| MutationSimple | KRAS | p.Gly13Cys (c.37G>T) | Heterozygous | - | Unknown, Unknown, PubMed=28273451, PubMed=25230021, PubMed=24224046, PubMed=22705003 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Velculescu V.E., Scharpf R.B.
Cell Rep. 25:2617-2633(2018).
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Drapkin R.I., Ailles L., Mes-Masson A.-M., Rottapel R.
Cell Rep. 18:2343-2358(2017).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.
Itamochi H., Bodenmiller B., Erler J.T., Turk B.E., Linding R.
Cell 163:202-217(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
Helleman J.
PLoS ONE 9:E103988-E103988(2014).
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.
PLoS ONE 8:E80229-E80229(2013).
Type-specific cell line models for type-specific ovarian cancer research.
Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.
PLoS ONE 8:E72162-E72162(2013).
Evaluating cell lines as tumour models by comparison of genomic profiles.
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Nat. Commun. 4:2126.1-2126.10(2013).
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Lessey B.A., Jordan V.C., Bradford A.P.
Gynecol. Oncol. 127:241-248(2012).
Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.
Miyazaki K.
Hum. Pathol. 43:2197-2206(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
Long S.B.T., Vonguyen L., Chen D.J., Gray J.W., Chen F.-Q.
Oncol. Rep. 23:1021-1026(2010).
A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.";
Anderson M.L., Matzuk M.M.
Mol. Endocrinol. 24:447-463(2010).
Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells.
Jacobs I.J., Jones C., Gayther S.A.
Int. J. Cancer 124:1037-1044(2009).
Microarray analysis of gene expression mirrors the biology of an ovarian cancer model.
Manderson E.N., Provencher D.M., Mes-Masson A.-M.
Oncogene 20:6617-6626(2001).