YSCCCHomo sapiens (Human)Cancer cell line
Also known as: CCC
🤖 AI SummaryBased on 3 publications
Quick Overview
Human cholangiocarcinoma cell line with IDH mutations and dasatinib sensitivity.
Detailed Summary
The YSCCC cell line is a human cholangiocarcinoma cell line derived from intrahepatic bile ducts. It exhibits isocitrate dehydrogenase (IDH) mutations, which are associated with increased sensitivity to the multi-kinase inhibitor dasatinib. Research has shown that YSCCC cells are highly responsive to dasatinib, demonstrating significant growth inhibition and apoptosis in both in vitro and in vivo models. This cell line is valuable for studying the molecular mechanisms of IDH mutations in cholangiocarcinoma and for evaluating targeted therapies such as SRC inhibitors. Additionally, YSCCC has been used to investigate gemcitabine resistance mechanisms, showing upregulation of ribonucleotide reductase (RNR) subunits and altered metabolic pathways. These characteristics make YSCCC a critical tool for understanding cholangiocarcinoma biology and developing novel therapeutic strategies.
Research Applications
IDH mutation analysisDasatinib sensitivity testingSRC dependency studiesGemcitabine resistance mechanismsMetabolic pathway investigation
Key Characteristics
IDH mutationsDasatinib hypersensitivitySRC dependencyGemcitabine resistanceAltered RNR expression
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3629 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Donor Information
| Age | 70 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Cholangiocarcinoma |
|---|---|
| Lineage | Biliary Tract |
| Subtype | Intrahepatic Cholangiocarcinoma |
| OncoTree Code | IHCH |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001864_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
12
D16S539
10,11
D18S51
14
D21S11
30
D3S1358
15,16
D5S818
10,12
D7S820
10,11
D8S1179
13,16
FGA
22,23
Penta D
9
Penta E
5,18
TH01
7,9
TPOX
11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
Vazquez F., Getz G., Bardeesy N.M.
bioRxiv 2024:07.04.601970-07.04.601970(2024).
Development and characterization of human primary cholangiocarcinoma cell lines.
Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Am. J. Pathol. 192:1200-1217(2022).
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Jirawatnotai S.
Hepatology 70:1614-1630(2019).
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Bardeesy N.M.
Cancer Discov. 6:727-739(2016).
Statins induce apoptosis and inhibit proliferation in cholangiocarcinoma cells.
Kosaka K., Chayama K.
Int. J. Oncol. 39:561-568(2011).