TO 175.THomo sapiens (Human)Undefined cell line type
Also known as: TO175T, TO-175-T
🤖 AI SummaryBased on 4 publications
Quick Overview
Skin fibroblast cell line for cancer research and drug sensitivity studies.
Detailed Summary
TO 175.T is a skin fibroblast cell line derived from human tissue. It is utilized in cancer research, particularly in studies related to drug sensitivity and anticancer drug response modeling. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE), which provides comprehensive genomic and pharmacological data for preclinical cancer research. While specific details about its genetic profile and disease context are not provided, its inclusion in large-scale genomic studies suggests its relevance in understanding cancer biology and therapeutic responses. Researchers use such cell lines to identify predictors of drug sensitivity and to develop personalized treatment strategies.
Research Applications
Cancer researchDrug sensitivity studiesAnticancer drug response modeling
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used in preclinical cancer research
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3806 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Trunk, skin[UBERON:UBERON_0001085] |
Donor Information
| Age | 29 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Non-Cancerous |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000125_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
10,14
D16S539
10,11
D18S51
11,14
D19S433
14,15
D21S11
30
D2S1338
17
D3S1358
14,18
D5S818
10,11
D7S820
11,12
D8S1179
13
FGA
21,22
Penta D
9,13
Penta E
5,12
TH01
7,8
TPOX
10,12
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
J. Virol. 89:713-729(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Fibroblasts cell lines misclassified as cancer cell lines.";
de Weck A., Bitter H., Kauffmann A.
bioRxiv 2017:166199-166199(2017).