WPE1-NA22Homo sapiens (Human)Transformed cell line
Also known as: WPE1NA22
🤖 AI SummaryBased on 3 publications
Quick Overview
Human prostate epithelial cell line for cancer research.
Detailed Summary
WPE1-NA22 is a human prostate epithelial cell line derived from the RWPE-1 cell line through transformation with N-methyl-N-nitrosourea (MNU). It exhibits progressive malignant characteristics, including increased invasiveness and tumorigenicity. The cell line shows a distinct epithelial morphology and expresses prostatic markers such as androgen receptor (AR) and prostate-specific antigen (PSA) in response to androgens. WPE1-NA22 demonstrates intermediate tumorigenicity and invasive potential compared to other MNU-derived cell lines, making it a valuable model for studying prostate cancer progression. It is used in research on carcinogenesis, tumor progression, and chemoprevention.
Research Applications
CarcinogenesisTumor ProgressionChemopreventionAndrogen Response Studies
Key Characteristics
Expresses AR and PSA in response to androgensIntermediate tumorigenicityIncreased invasiveness compared to non-transformed cellsEpithelial morphology with some spindle-shaped features
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3810 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Prostate, epithelium[UBERON:UBERON_0000428] |
Donor Information
| Age | 54 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Non-Cancerous |
|---|---|
| Lineage | Fibroblast |
| Subtype | Fibroblast, Soft Tissue |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001422_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13
D13S317
14
D16S539
9,11
D18S51
14
D19S433
13
D21S11
29,31
D2S1338
17
D3S1358
15,16
D5S818
12,15
D7S820
10,11
D8S1179
10,14
FGA
25
Penta D
10,13
Penta E
5,12
TH01
8,9.3
TPOX
8,11
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Cell lines used in prostate cancer research: a compendium of old and new lines -- part 2.
Sobel R.E., Sadar M.D.
J. Urol. 173:360-372(2005).