Li-7Homo sapiens (Human)Cancer cell line
Also known as: C-Li-7, Li7, LI7
Quick Overview
Human hepatocellular carcinoma cell line with cancer stem cell properties.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_3840 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 45 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Adult hepatocellular carcinoma |
|---|---|
| Lineage | Liver |
| Subtype | Hepatocellular Carcinoma |
| OncoTree Code | HCC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000471_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7.
Sasaki R., Hirai M.Y., Hyodo I., Tsuchiya K., Nakamura Y.
Hum. Cell 36:2074-2086(2023).
A pharmacogenomic landscape in human liver cancers.";
Hui L.-J.
Cancer Cell 36:179-193.e11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Gastroenterology 157:760-776(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A robust culture method for maintaining tumorigenic cancer stem cells in the hepatocellular carcinoma cell line Li-7.
Nakamura Y.
Cancer Sci. 110:1644-1652(2019).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
Nat. Commun. 4:2218.1-2218.7(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Yamori T.
Mol. Cancer Ther. 4:399-412(2005).
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.
Inazawa J.
Hepatology 35:1476-1484(2002).
Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma.
Tsuda H., Hirohashi S., Shimosato Y., Ino Y., Yoshida T., Terada M.
Jpn. J. Cancer Res. 80:196-199(1989).
Production of alpha-fetoprotein and normal serum proteins by xenotransplanted human hepatomas in relation to their growth and morphology.
Taguchi Y., Kageyama K.
Cancer Res. 39:1819-1828(1979).