HHUAHomo sapiens (Human)Cancer cell line

Also known as: HHUA-1

🤖 AI SummaryBased on 5 publications

Quick Overview

HHUA is a human endometrial adenocarcinoma cell line established from a well-differentiated tumor.

Detailed Summary

HHUA is a human endometrial adenocarcinoma cell line established from a well-differentiated tumor. It exhibits characteristics of epithelial cells, forming multilayers without contact inhibition. The cell line shows a stable proliferation over long periods and has been subcultivated multiple times. HHUA cells contain both estradiol-17β and progesterone receptors, and their receptor levels can be modulated by hormone administration. Additionally, HHUA has been used in studies related to tumor angiogenesis and genetic alterations, including Rb gene changes and p53 mutations. The cell line is transplantable in nude mice, forming tumors that resemble adenocarcinomas. These properties make HHUA a valuable tool for studying endometrial cancer biology and therapeutic responses.

Research Applications

Tumor angiogenesisGenetic alterations (Rb, p53)Hormone receptor studiesIn vivo transplantation (nude mice)

Key Characteristics

Epithelial morphologyNo contact inhibitionStable long-term proliferationEstradiol-17β and progesterone receptorsTransplantable in nude mice

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3866
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	54
Age Category	Adult
Sex	Female

Disease Information

Disease	Endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	RIKEN
Source ID	ACH-002026_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ala138Val (c.413C>T)	Unspecified	-	PubMed=8105795

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

8,11

D16S539

10,12

D18S51

12,18,19

D21S11

29,30

D3S1358

14,15

D5S818

9,12,13,14

D7S820

10,13

D8S1179

11,13

FGA

21,22

Penta D

8,11

Penta E

11,13

TH01

6,7

TPOX

8,9

vWA

17,18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.

Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.

Pathol. Res. Pract. 201:109-115(2005).

DOI PubMed

Tumor angiogenesis factors produced by cancer cells.";

Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.

Hum. Cell 12:37-46(1999).

PubMed

Effects of feeder cells (human cancer cell lines) on the development of mouse embryos by co-culture.

Ishikawa H.

Hum. Cell 10:237-246(1997).

PubMed

Tissue reconstruction of gynecologic tumor cells in the rotation culture system.

Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.

Hum. Cell 10:175-181(1997).

PubMed

Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma.

Nomura T.

Mol. Carcinog. 8:132-137(1993).

DOI PubMed

Establishment of human endometrial adenocarcinoma cell line containing estradiol-17 beta and progesterone receptors.

Ishiwata I., Ishiwata C., Soma M., Arai J., Ishikawa H.

Gynecol. Oncol. 17:281-290(1984).

DOI PubMed

Effects of estradiol-17 beta and progesterone on cell proliferation and differentiation of the human endometrial carcinoma cell line (HHUA) in vitro.

Ishiwata I., Ishiwata C., Ishikawa H.

Asia Oceania J. Obstet. Gynaecol. 10:531-538(1984).

DOI PubMed

Tumor angiogenic activity of gynecologic tumor cell lines on the chorioallantoic membrane.

Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.

Gynecol. Oncol. 29:87-93(1988).

DOI PubMed

CA125 production by gynecologic tumors in vitro and its modulation induced by dibutyl cyclic adenosine monophosphate.

Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.

Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986).

DOI PubMed

Web Resources

iclac.org cell.brc.riken.jp