HOUA-IHomo sapiens (Human)Cancer cell line
Also known as: HOUA, HOUAI, HOUA-1, HOOUA
🤖 AI SummaryBased on 4 publications
Quick Overview
Human endometrial adenocarcinoma cell line with CA125 production and p53 mutations.
Detailed Summary
HOUA-I is a human endometrial adenocarcinoma cell line that has been studied for its CA125 production and response to dbcAMP. It was found to produce CA125 at a concentration of 146 U/ml in conditioned media. The cell line also exhibits p53 mutations, with specific alterations noted in exons 4-5 and 7-8. Additionally, HOUA-I shows intermediate expression of p53 protein and is part of studies examining the relationship between DNA alterations and protein expression in cancer cell lines. The cell line has been used in research on tumor angiogenic activity and has demonstrated neovascularization in CAM assays. HOUA-I is also involved in studies of the Rb gene and its association with p53 and Ki-ras mutations in endometrial adenocarcinoma.
Research Applications
CA125 productiondbcAMP responsep53 mutation analysistumor angiogenesisRb gene alterationsKi-ras mutation analysis
Key Characteristics
CA125 production at 146 U/mlp53 mutations in exons 4-5 and 7-8intermediate p53 protein expressionneovascularization in CAM assaysRb gene alterationsKi-ras mutations
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3867 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Endometrium[UBERON:UBERON_0001295] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Endometrial carcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Endometrial Carcinoma |
| OncoTree Code | UCEC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-002027_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg282Trp (c.844C>T) | Unspecified | - | PubMed=21173094, PubMed=1373872 |
| MutationSimple | KRAS | p.Gly12Cys (c.34G>T) | Unspecified | - | PubMed=21173094 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13,14,15
D13S317
13,14,15
D16S539
9,13,14
D18S51
17,18,19,23,24,25
D21S11
31,32
D3S1358
16,17
D5S818
12,13,14,15
D7S820
10,11,12
D8S1179
12,13,15
FGA
17,21
Penta D
11
Penta E
13,15,16
TH01
6,9
TPOX
8,9
vWA
18,19,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Pathol. Res. Pract. 201:109-115(2005).
Tumor angiogenesis factors produced by cancer cells.";
Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.
Hum. Cell 12:37-46(1999).
Tissue reconstruction of gynecologic tumor cells in the rotation culture system.
Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.
Hum. Cell 10:175-181(1997).
Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma.
Nomura T.
Mol. Carcinog. 8:132-137(1993).
Tumor angiogenic activity of gynecologic tumor cell lines on the chorioallantoic membrane.
Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.
Gynecol. Oncol. 29:87-93(1988).