SNU-216Homo sapiens (Human)Cancer cell line

Also known as: NCI-SNU-216, SNU216

🤖 AI SummaryBased on 8 publications

Quick Overview

SNU-216 is a gastric cancer cell line used in cancer research.

Detailed Summary

SNU-216 is a gastric cancer cell line derived from a human gastric tumor. It is widely used in research to study the molecular mechanisms of gastric cancer and to develop targeted therapies. The cell line has been characterized for its genetic and molecular profiles, including mutations and gene expression patterns. Research on SNU-216 has contributed to understanding the role of specific genes and pathways in gastric cancer progression. It is also used to evaluate the efficacy of anticancer drugs and to identify potential biomarkers for diagnosis and treatment.

Generated on 6/20/2025

Basic Information

Database ID	CVCL_3946
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	46
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Gastric tubular adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Tubular Stomach Adenocarcinoma
OncoTree Code	TSTAD

DepMap Information

Source Type	KCLB
Source ID	ACH-000466_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val216Met (c.646G>A)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

10,13

D18S51

D21S11

30,33.2

D3S1358

D5S818

D7S820

8,10

D8S1179

13,16

FGA

Penta D

9,13

Penta E

TH01

TPOX

vWA

14,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

DOI PubMed PMC

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

DOI PubMed PMC

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

DOI PubMed PMC

Establishment and characterization of human gastric carcinoma cell lines.

Bang Y.-J., Kim Y.I., Kim J.-P.

Int. J. Cancer 70:443-449(1997).

DOI PubMed