LN-340Homo sapiens (Human)Cancer cell line
Also known as: LN340, LN 340
🤖 AI SummaryBased on 4 publications
Quick Overview
LN-340 is a human glioma cell line with known genetic alterations in TP53, p16, p14ARF, and PTEN.
Detailed Summary
LN-340 is a human glioma cell line derived from a de novo glioblastoma. It exhibits frequent co-alterations in the TP53, p16/CDKN2A, p14ARF, and PTEN tumor suppressor genes, which are critical in the development and progression of gliomas. These genetic alterations include mutations or deletions in TP53, p16, and p14ARF, as well as PTEN mutations. The cell line is used in research to study the molecular mechanisms of glioblastoma and to evaluate therapeutic strategies targeting these genetic alterations. LN-340 has been characterized in multiple studies for its genetic profile and tumorigenic potential in immunocompromised mice.
Research Applications
Genetic analysis of tumor suppressor genesStudy of glioblastoma molecular mechanismsEvaluation of therapeutic strategies targeting genetic alterations
Key Characteristics
Frequent co-alterations in TP53, p16, p14ARF, and PTENMutations or deletions in tumor suppressor genesTumorigenic in immunocompromised mice
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3955 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain, right parietal lobe[UBERON:UBERON_0002803] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Glioblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000634_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg181Pro (c.542G>C) | Homozygous | - | Unknown, PubMed=10416987 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
11,12
D16S539
11,14
D18S51
14,18
D21S11
28,32.2
D3S1358
15
D5S818
11,12
D7S820
11,12
D8S1179
14
FGA
21,25
Penta D
12,15
Penta E
5,9
TH01
7,9.3
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Hamou M.-F., Delorenzi M., Hegi M.E.
Neuro-oncol. 14:701-711(2012).
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Van Meir E.G.
Brain Pathol. 9:469-479(1999).
Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas.
Diserens A.-C., Van Meir E.G.
Cancer Res. 53:5345-5349(1993).