LN-382Homo sapiens (Human)Cancer cell line
Also known as: LN382, LN 382
🤖 AI SummaryBased on 3 publications
Quick Overview
Human glioblastoma cell line for cancer research.
Detailed Summary
LN-382 is a human glioblastoma cell line derived from a brain tumor. It is used in cancer research to study tumor biology, genetic mutations, and therapeutic responses. The cell line has been utilized in studies involving genome-wide screening and identification of genetic dependencies in cancer cells. LN-382 is part of a panel of cell lines used to investigate the molecular mechanisms of glioblastoma and other cancers. Its applications include drug screening, understanding tumor progression, and exploring the role of specific genes in cancer development.
Research Applications
Cancer researchGenome-wide screeningDrug screeningTumor biologyGenetic dependencies
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3956 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain, right fronto-parietal lobe |
Donor Information
| Age | 67 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Glioblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000215_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Val197Leu (c.589G>T) | Homozygous | - | PubMed=10416987 |
| MutationSimple | RB1 | p.Arg320Ter (c.958C>T) | Heterozygous | - | PubMed=25326674 |
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
The human melanoma antigen-encoding gene, MAGE-1, is expressed by other tumour cells of neuroectodermal origin such as glioblastomas and neuroblastomas.
Rimoldi D., Romero P., Carrel S.
Int. J. Cancer 54:527-528(1993).
Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas.
Diserens A.-C., Van Meir E.G.
Cancer Res. 53:5345-5349(1993).