LN-464Homo sapiens (Human)Cancer cell line
Also known as: LN464, LN 464
🤖 AI SummaryBased on 4 publications
Quick Overview
Human glioblastoma cell line with TP53 and PTEN mutations.
Detailed Summary
LN-464 is a human glioblastoma cell line derived from a male patient with a tumor located in the right parietal lobe. This cell line exhibits mutations in the TP53 gene and alterations in the PTEN tumor suppressor gene. The genetic profile of LN-464 indicates co-alterations in multiple tumor suppressor pathways, including those involving p53, p16, and PTEN. These alterations are associated with the development of glioblastoma and may contribute to the aggressive nature of this cancer. LN-464 is used in research to study the molecular mechanisms underlying glioblastoma progression and to evaluate potential therapeutic strategies.
Research Applications
Glioblastoma researchTP53 mutation analysisPTEN mutation analysisTumor suppressor pathway studies
Key Characteristics
TP53 mutationPTEN mutationCo-alterations in tumor suppressor genes
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_3962 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 67 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000676_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Phe113Ser (c.338T>C) | Unspecified | - | Unknown |
| MutationSimple | PTEN | p.Asn184fs*6 (c.545_546insA) | Heterozygous | - | Unknown, PubMed=10416987 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
11,13
D16S539
11
D18S51
16
D21S11
28
D3S1358
16
D5S818
12
D7S820
10,13
D8S1179
12,13
FGA
22
Penta D
9
Penta E
10,14
TH01
9
TPOX
9,12
vWA
14,17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Hamou M.-F., Delorenzi M., Hegi M.E.
Neuro-oncol. 14:701-711(2012).
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Van Meir E.G.
Brain Pathol. 9:469-479(1999).
The human melanoma antigen-encoding gene, MAGE-1, is expressed by other tumour cells of neuroectodermal origin such as glioblastomas and neuroblastomas.
Rimoldi D., Romero P., Carrel S.
Int. J. Cancer 54:527-528(1993).
Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas.
Diserens A.-C., Van Meir E.G.
Cancer Res. 53:5345-5349(1993).