UACC-3199Homo sapiens (Human)Cancer cell line
Also known as: University of Arizona Cell Culture-3199, UACC3199, UACC 3199
🤖 AI SummaryBased on 1 publications
Quick Overview
Breast cancer cell line with BRCA1 methylation
Detailed Summary
UACC-3199 is a breast cancer cell line derived from sporadic breast tumors. It exhibits significant cytosine methylation in the BRCA1 CpG island promoter region, leading to reduced BRCA1 mRNA expression. This cell line was used in studies investigating the role of epigenetic modifications in breast cancer progression. The methylation pattern in UACC-3199 is associated with a eightfold decrease in BRCA1 mRNA levels compared to normal breast cells, suggesting a mechanism of gene repression in sporadic breast cancer.
Research Applications
Epigenetic regulationBRCA1 gene expressionBreast cancer research
Key Characteristics
Aberrant methylation of BRCA1 CpG islandReduced BRCA1 mRNA expressionSpontaneous breast tumor origin
Generated on 6/20/2025
Basic Information
| Database ID | CVCL_4042 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Axillary lymph node[UBERON:UBERON_0001097] |
Donor Information
| Age | 58 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Subtype Features | HER2+ |
Disease Information
| Disease | Invasive breast carcinoma of no special type |
|---|---|
| Lineage | Breast |
| Subtype | Breast Invasive Ductal Carcinoma |
| OncoTree Code | IDC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-002499_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
11
D16S539
12
D18S51
20
D19S433
16
D21S11
30.2
D2S1338
23
D3S1358
18
D5S818
13
D7S820
10
D8S1179
11,13
FGA
23
Penta D
12
Penta E
12
TH01
9.3
TPOX
10,13
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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