T3M-4Homo sapiens (Human)Cancer cell line

Also known as: Panc 89, PANC-89, Panc-89, Panc89, T3M4

🤖 AI SummaryBased on 5 publications

Quick Overview

Human pancreatic ductal adenocarcinoma cell line with known genetic alterations.

Detailed Summary

T3M-4 is a human pancreatic ductal adenocarcinoma cell line derived from a primary tumor. It exhibits frequent mutations in the K-ras, p53, and p16 genes, which are commonly associated with pancreatic cancer progression. The cell line is used in studies focusing on genetic alterations, drug sensitivity, and tumor biology. Its genetic profile makes it a valuable model for investigating the molecular mechanisms underlying pancreatic cancer development and therapeutic resistance.

Research Applications

Genetic alteration studiesDrug sensitivity and resistanceTumor biology and progression

Key Characteristics

K-ras mutationp53 mutationp16 mutation

Generated on 6/20/2025

Basic Information

Database ID	CVCL_4056
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	64
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Pancreatic ductal adenocarcinoma
Lineage	Pancreas
Subtype	Pancreatic Adenocarcinoma
OncoTree Code	PAAD

DepMap Information

Source Type	RIKEN
Source ID	ACH-000085_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr220Cys (c.659A>G)	Unspecified	-	PubMed=21173094
MutationSimple	KRAS	p.Gln61His (c.183A>C)	Heterozygous	1 of 3 alleles	Unknown, PubMed=8426738

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

D12S391

20,21,24

D13S317

10,13

D16S539

11,12

D18S51

D19S433

D1S1656

14,19.3

D21S11

32.2,33.2

D22S1045

15,16

D2S1338

17,25

D2S441

11,14

D3S1358

D5S818

D6S1043

10,11

D7S820

D8S1179

FGA

Penta D

Penta E

11,12

TH01

9.3

TPOX

11,12

vWA

18,19,21

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling.

Schackert H.K., Kloppel G., Kalthoff H., Saeger H.-D., Grutzmann R.

J. Cell. Mol. Med. 12:2823-2835(2008).

DOI PubMed PMC

A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform.

Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.

Virchows Arch. 442:444-452(2003).

DOI PubMed

Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.

Lohr J.-M., Scarpa A.

Virchows Arch. 439:798-802(2001).

DOI PubMed

Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.

Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.

Int. J. Cancer 91:350-358(2001).

DOI PubMed

p53 and K-RAS alterations in pancreatic epithelial cell lesions.";

Maurer J., Maacke H., Deppert W.

Oncogene 8:289-298(1993).

PubMed

Establishment and characterization of a carcinoembryonic antigen (CEA)-producing cell line from a human carcinoma of the exocrine pancreas.

Okabe T., Yamaguchi N., Ohsawa N.

Cancer 51:662-668(1983).

DOI PubMed

Web Resources

cellosaurus.org