MM466Homo sapiens (Human)Cancer cell line

MM466 is a melanoma cell line that has been extensively studied for its BRAF mutation status. Research indicates that MM466 carries the V599E mutation in the BRAF gene, which is a common mutation associated with melanoma. This mutation leads to constitutive activation of the MAPK pathway, contributing to tumor progression. Studies have identified a BRAF mutation-associated gene expression signature in MM466, which includes upregulated genes such as TBX3 and downregulated genes like TR@A. Additionally, MM466 has been used in genome-wide analyses to identify loss of heterozygosity (LOH) and copy number changes, revealing frequent LOH on chromosome arms 9p, 10p, 10q, 9q, 6q, 11q, and 17p. The cell line has also been part of studies examining the role of BRAF mutations in melanoma development and therapeutic targeting.