MM473Homo sapiens (Human)Cancer cell line
Also known as: MM 473
🤖 AI SummaryBased on 3 publications
Quick Overview
MM473 is a melanoma cell line with BRAF mutation.
Detailed Summary
MM473 is a melanoma cell line with a BRAF mutation, specifically the V599E mutation. This mutation is associated with the activation of the MAPK pathway, which is a key driver in melanoma development. The cell line has been used in studies to identify gene expression signatures linked to BRAF mutations. Research has shown that MM473 exhibits a distinct gene expression profile that can be used to predict BRAF mutation status. The cell line is also part of a panel used to study loss of heterozygosity and copy number changes in melanoma.
Research Applications
BRAF mutation analysisGene expression profilingLoss of heterozygosity (LOH) analysisCopy number variation (CNV) analysis
Key Characteristics
BRAF V599E mutationDistinct gene expression signatureUsed in melanoma research
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4450 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | CellBank Australia |
|---|---|
| Source ID | ACH-001972_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | CDKN2A | p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T) | Unspecified | - | PubMed=11787853 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,12
D13S317
8,12
D16S539
11,12
D18S51
12,14
D19S433
12,14
D21S11
30.2,32.2
D2S1338
17
D3S1358
14,15
D5S818
12
D7S820
9,11
D8S1179
13,15
FGA
22,23
TH01
9,9.3
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Johansson P., Pavey S., Hayward N.K.
Pigment Cell Res. 20:216-221(2007).
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Stark M.S., Hayward N.K.
Cancer Res. 67:2632-2642(2007).
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Meltzer P.S., Ringner M., Hayward N.K.
Oncogene 23:4060-4067(2004).
CDKN2A/p16 is inactivated in most melanoma cell lines.";
Gabrielli B.G., Parsons P.G., Hayward N.K.
Cancer Res. 57:4868-4875(1997).
Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.
Chenevix-Trench G., Martin N.G., Ellem K.A.O.
Oncogene 5:1187-1193(1990).