MM537Homo sapiens (Human)Cancer cell line
Also known as: MM 537
🤖 AI SummaryBased on 3 publications
Quick Overview
MM537 is a melanoma cell line with BRAF mutation, used in cancer research.
Detailed Summary
MM537 is a melanoma cell line derived from human tissue, characterized by a BRAF mutation. It is utilized in research to study the molecular mechanisms of melanoma, particularly focusing on the role of BRAF mutations in tumor development and progression. The cell line has been analyzed for its gene expression profiles and has shown specific signatures associated with BRAF mutations, which are important for understanding the genetic basis of melanoma. This cell line is part of a panel used to identify potential therapeutic targets and to evaluate the effectiveness of targeted therapies.
Research Applications
Cancer researchGene expression profilingBRAF mutation analysis
Key Characteristics
BRAF mutationMelanoma cell line
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4451 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | CellBank Australia |
|---|---|
| Source ID | ACH-001974_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
12
D16S539
11,12
D18S51
12
D19S433
12,14
D21S11
28,32.2
D2S1338
18,24
D3S1358
14,15
D5S818
11,12
D7S820
12
D8S1179
12
FGA
20,24
TH01
6
TPOX
8,10
vWA
14,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Johansson P., Pavey S., Hayward N.K.
Pigment Cell Res. 20:216-221(2007).
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Stark M.S., Hayward N.K.
Cancer Res. 67:2632-2642(2007).