BDCMHomo sapiens (Human)Cancer cell line
Also known as: B-cell with DC Morphology
🤖 AI SummaryBased on 4 publications
Quick Overview
BDCM is a B-cell line with dendritic cell-like properties, showing cross-priming and strong antigen-presenting capabilities.
Detailed Summary
BDCM is a B-cell line that exhibits characteristics similar to dendritic cells, including extensive surface projections, cross-priming ability, and strong T cell-stimulating capability. It was derived from a patient with M5a myeloid leukemia and shows unique genetic and functional similarities to dendritic cells. BDCM cells express high levels of HLA-DR and co-stimulatory molecules like CD86, making them effective antigen-presenting cells. They also produce cytokine profiles similar to mature dendritic cells, suggesting potential applications in immunotherapy research. The cell line's ability to cross-prime T cells and its autocrine activation of Stat-1 highlight its relevance in studying immune responses and cancer immunology.
Research Applications
Immunotherapy researchAntigen presentation studiesDendritic cell-like function analysisCytokine profile investigation
Key Characteristics
Cross-priming abilityStrong T cell-stimulating capabilityExpression of HLA-DR and CD86Autocrine Stat-1 activation
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4613 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age Category | Pediatric |
|---|---|
| Sex | Male |
Disease Information
| Disease | Acute myeloid leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Acute Monoblastic/Monocytic Leukemia |
| OncoTree Code | AMOL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000080_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
11
D16S539
10,11
D18S51
12,18
D19S433
13,13.1,14
D21S11
29,30
D2S1338
19
D3S1358
15,16
D5S818
12,13
D7S820
9,11
D8S1179
14,15
FGA
21,24
Penta D
9,11
Penta E
10,17
TH01
6,9.3
TPOX
9,10
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).