JHOC-5Homo sapiens (Human)Cancer cell line

Also known as: JHOC5

🤖 AI SummaryBased on 10 publications

Quick Overview

Human ovarian cancer cell line with potential for research in high-grade serous carcinoma.

Detailed Summary

JHOC-5 is a human ovarian cancer cell line derived from a high-grade serous carcinoma, a common and aggressive subtype of ovarian cancer. This cell line is utilized in research to study the molecular characteristics and therapeutic responses of high-grade serous ovarian cancer. It is part of a panel of cell lines used to evaluate genomic profiles and drug sensitivity, contributing to the development of targeted therapies. JHOC-5 has been analyzed for its genetic mutations and expression profiles, providing insights into the mechanisms of cancer progression and treatment resistance. Its use in studies helps in understanding the complexities of ovarian cancer and in identifying potential biomarkers for diagnosis and treatment.

Research Applications

Genomic profilingDrug sensitivity testingMolecular mechanism studiesTherapeutic target identification

Key Characteristics

High-grade serous carcinoma originGenetic mutations in key oncogenesExpression profiles for drug response analysis

Generated on 6/21/2025

Basic Information

Database ID	CVCL_4640
Species	Homo sapiens (Human)
Tissue Source	Ovary[UBERON:UBERON_0000992]

Donor Information

Age	47
Age Category	Adult
Sex	Female

Disease Information

Disease	Clear cell adenocarcinoma of the ovary
Lineage	Ovary/Fallopian Tube
Subtype	Clear Cell Ovarian Cancer
OncoTree Code	CCOV

DepMap Information

Source Type	RIKEN
Source ID	ACH-000324_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

9,12

D16S539

11,13

D5S818

D7S820

TH01

TPOX

vWA

14,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice.

Herodek B., Arteagabeitia A.B., Valenti M., Kirkin V.

Sci. Rep. 10:10799-10799(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.

Drapkin R.I., Ailles L., Mes-Masson A.-M., Rottapel R.

Cell Rep. 18:2343-2358(2017).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.

Ichikawa H., Shibata T., Yokota J., Okamoto A., Kohno T.

Int. J. Oncol. 46:2389-2398(2015).

DOI PubMed

Type-specific cell line models for type-specific ovarian cancer research.

Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.

PLoS ONE 8:E72162-E72162(2013).

DOI PubMed PMC

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

DOI PubMed PMC

Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.

Miyazaki K.

Hum. Pathol. 43:2197-2206(2012).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Establishment and characterization of cell lines derived from serous adenocarcinoma (JHOS-2) and clear cell adenocarcinoma (JHOC-5, JHOC-6) of human ovary.

Endoh H., Kimura E., Yasuda M., Tanaka T., Ishikawa H.

Hum. Cell 12:131-138(1999).

PubMed