JHOM-1Homo sapiens (Human)Cancer cell line
Also known as: JHOM1
🤖 AI SummaryBased on 7 publications
Quick Overview
Human ovarian cancer cell line for research on molecular mechanisms and drug sensitivity.
Detailed Summary
JHOM-1 is a human ovarian cancer cell line derived from a high-grade serous carcinoma. It is widely used in studies focusing on genomic profiling, drug sensitivity, and molecular mechanisms of cancer progression. Research has shown that JHOM-1 exhibits specific genetic alterations, including mutations in TP53 and other key oncogenes, making it a valuable model for investigating targeted therapies. The cell line is also utilized in comparative studies to evaluate the effectiveness of various anticancer drugs and to understand the relationship between genetic profiles and treatment responses.
Research Applications
Genomic profilingDrug sensitivity testingMolecular mechanism studiesComparative drug efficacy analysis
Key Characteristics
TP53 mutationHigh-grade serous carcinoma originUsed in drug response studies
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4644 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ovary[UBERON:UBERON_0000992] |
Donor Information
| Age | 88 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Mucinous adenocarcinoma of ovary |
|---|---|
| Lineage | Ovary/Fallopian Tube |
| Subtype | Mucinous Ovarian Cancer |
| OncoTree Code | MOV |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000237_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg213Ter (c.637C>T) | Unspecified | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
8,12
D16S539
10,11
D5S818
10
D7S820
10.3,12
TH01
7,9
TPOX
8,11
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Velculescu V.E., Scharpf R.B.
Cell Rep. 25:2617-2633(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
Evaluating cell lines as tumour models by comparison of genomic profiles.
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Nat. Commun. 4:2126.1-2126.10(2013).