JHOM-2BHomo sapiens (Human)Cancer cell line
Also known as: JHOM2B
🤖 AI SummaryBased on 4 publications
Quick Overview
Human cell line for cancer research, unknown tissue and disease origin.
Detailed Summary
JHOM-2B is a human cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for genomic profiles, including copy-number alterations, mutations, and mRNA expression. Research suggests that JHOM-2B may have characteristics relevant to ovarian cancer studies, though its specific applications and features require further investigation. The cell line's genomic data provides insights into potential models for cancer research, particularly in understanding tumor heterogeneity and drug sensitivity.
Research Applications
Genomic profilingCancer researchDrug sensitivity studies
Key Characteristics
Genomic data availablePart of CCLEPotential relevance to ovarian cancer
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4645 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ovary[UBERON:UBERON_0000992] |
Donor Information
| Age | 56 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Mucinous adenocarcinoma of ovary |
|---|---|
| Lineage | Ovary/Fallopian Tube |
| Subtype | Mucinous Ovarian Cancer |
| OncoTree Code | MOV |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000333_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys275Phe (c.824G>T) | Homozygous | - | PubMed=29970484, PubMed=8782485, PubMed=8725545 |
| MutationSimple | RB1 | p.Arg552Ter (c.1654C>T) | Homozygous | - | Unknown, Unknown |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
11
D16S539
9,13
D5S818
10,11
D7S820
10,11
TH01
7
TPOX
8,10
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Evaluating cell lines as tumour models by comparison of genomic profiles.
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Nat. Commun. 4:2126.1-2126.10(2013).