JHOS-2Homo sapiens (Human)Cancer cell line

Also known as: JHOS2

🤖 AI SummaryBased on 6 publications

Quick Overview

Human high-grade serous ovarian cancer cell line for research.

Detailed Summary

JHOS-2 is a human high-grade serous ovarian cancer (HGSOC) cell line derived from ovarian tissue. It is used in research to study the molecular characteristics and therapeutic responses of HGSOC. The cell line has been analyzed for genomic and proteomic profiles, showing similarities to HGSOC tumors in terms of copy-number alterations, mutations, and gene expression. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies evaluating drug sensitivity and molecular subtyping. JHOS-2 is noted for its genomic features that make it a suitable model for HGSOC research, although it is not among the most commonly used cell lines in this context.

Research Applications

Genomic profilingProteomic analysisDrug sensitivity testingMolecular subtypingTherapeutic target identification

Key Characteristics

High-grade serous ovarian cancerGenomic similarity to HGSOC tumorsUsed in CCLE for drug response studiesExpression of key oncogenes and tumor suppressors

Generated on 6/21/2025

Basic Information

Database ID	CVCL_4647
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	45
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	High grade ovarian serous adenocarcinoma
Lineage	Ovary/Fallopian Tube
Subtype	High-Grade Serous Ovarian Cancer
OncoTree Code	HGSOC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000132_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.767_782+4delTGACCTGGAGTCTTCCAGTG	Unspecified	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

8,9

D16S539

D21S11

31,31.2

D5S818

D7S820

TH01

6,7

TPOX

8,11

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.

Velculescu V.E., Scharpf R.B.

Cell Rep. 25:2617-2633(2018).

DOI PubMed PMC

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.

Nat. Commun. 7:12645.1-12645.14(2016).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Establishment and characterization of cell lines derived from serous adenocarcinoma (JHOS-2) and clear cell adenocarcinoma (JHOC-5, JHOC-6) of human ovary.

Endoh H., Kimura E., Yasuda M., Tanaka T., Ishikawa H.

Hum. Cell 12:131-138(1999).

PubMed