JHUEM-3Homo sapiens (Human)Cancer cell line
Also known as: JHUEM3
🤖 AI SummaryBased on 2 publications
Quick Overview
Human cell line with unknown tissue and disease origin.
Detailed Summary
JHUEM-3 is a human cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and the Catalogue of Somatic Mutations in Cancer (COSMIC) databases, which provide genomic and pharmacological data for cancer research. The cell line's genetic and molecular characteristics are being studied to understand cancer biology and drug sensitivity. However, specific details about its tissue of origin, disease type, and cell type remain unknown. Further research is needed to fully characterize this cell line and its potential applications in cancer studies.
Research Applications
Cancer researchGenomic and pharmacological profiling
Key Characteristics
Part of CCLE and COSMIC databasesUsed for studying cancer biology and drug sensitivity
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4657 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Endometrium[UBERON:UBERON_0001295] |
Donor Information
| Age | 60 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Endometrial adenocarcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Endometrial Carcinoma |
| OncoTree Code | UCEC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000173_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln167Ter (c.499C>T) | Homozygous | - | Unknown |
| MutationSimple | KRAS | p.Asp33Glu (c.99T>A) | Heterozygous | - | Unknown |
| MutationSimple | FBXW7 | p.Arg465His (c.1394G>A) | Homozygous | - | Unknown, PubMed=26870252, PubMed=22675565 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
8,13
D16S539
9,11
D5S818
11
D7S820
9,11
TH01
7
TPOX
8,11
vWA
14,19,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).