PK-1Homo sapiens (Human)Cancer cell line

Also known as: PK1

🤖 AI SummaryBased on 8 publications

Quick Overview

Human pancreatic cancer cell line with metabolic and drug resistance characteristics.

Detailed Summary

PK-1 is a human pancreatic cancer cell line established from a liver metastasis of pancreatic ductal adenocarcinoma. It exhibits distinct metabolic characteristics, including reduced proliferative capacity and specific metabolic dependencies. PK-1 has been used to study drug resistance mechanisms, particularly in relation to gemcitabine, with evidence of DCK inactivation contributing to resistance. The cell line is also utilized in research on tumor metastasis, showing high metastatic potential in experimental models. PK-1 is valuable for investigating pancreatic cancer biology, including genetic alterations and therapeutic responses.

Research Applications

Metabolic profiling and drug resistance studiesTumor metastasis researchGenetic and molecular characterizationTherapeutic response evaluation

Key Characteristics

Metabolic subtype classificationGemcitabine resistance via DCK inactivationHigh metastatic potential in vivoGenetic alterations in K-ras, p53, p16, and SMAD4

Generated on 6/21/2025

Basic Information

Database ID	CVCL_4717
Species	Homo sapiens (Human)
Tissue Source	Liver[UBERON:UBERON_0002107]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Pancreatic ductal adenocarcinoma
Lineage	Pancreas
Subtype	Pancreatic Adenocarcinoma
OncoTree Code	PAAD

DepMap Information

Source Type	RIKEN
Source ID	ACH-000307_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Met237Ile (c.711G>A)	Homozygous	-	PubMed=22525470, PubMed=11221843, PubMed=7744731
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

9,10

D16S539

D18S51

D21S11

D3S1358

D5S818

11,12

D7S820

D8S1179

10,15

FGA

22,24

Penta D

Penta E

9,20

TH01

TPOX

9,11

vWA

15,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.

Ishida M., Motoi F., Egawa S., Unno M., Horii A.

Biochem. Biophys. Res. Commun. 421:98-104(2012).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.

Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.

Oncol. Rep. 8:89-92(2001).

DOI PubMed

Establishment of an experimental liver metastasis model by intraportal injection of a newly derived human pancreatic cancer cell line (KLM-1).

Matsuno S.

Int. J. Pancreatol. 20:43-50(1996).

DOI PubMed

Establishment of a human pancreatic cancer cell line and detection of pancreatic cancer associated antigen.

Kobari M., Matsuno S., Sato T., Kan M., Tachibana T.

Tohoku J. Exp. Med. 143:33-46(1984).

DOI PubMed

Establishment of six human pancreatic cancer cell lines and their sensitivities to anti-tumor drugs.

Kobari M., Hisano H., Matsuno S., Sato T., Kan M., Tachibana T.

Tohoku J. Exp. Med. 150:231-248(1986).

DOI PubMed