PK-8Homo sapiens (Human)Cancer cell line
Also known as: PK8
🤖 AI SummaryBased on 7 publications
Quick Overview
PK-8 is a human pancreatic cancer cell line used in cancer research.
Detailed Summary
PK-8 is a human pancreatic cancer cell line derived from a pancreatic tumor. It is widely used in research for studying pancreatic cancer biology, including genetic mutations, drug sensitivity, and metabolic profiles. The cell line has been characterized for its genetic alterations, such as mutations in the K-ras, p53, p16, and SMAD4 genes, which are common in pancreatic cancer. PK-8 is also utilized in studies involving metabolic reprogramming and the identification of therapeutic targets. Its use in in vitro and in vivo models helps researchers understand tumor progression and response to treatments.
Research Applications
Genetic mutation analysisDrug sensitivity testingMetabolic profilingIn vitro and in vivo tumor models
Key Characteristics
Mutations in K-ras, p53, p16, and SMAD4Used in cancer research for pancreatic cancer biologyCharacterized for metabolic reprogrammingUtilized in drug response studies
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4718 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Unknown |
Disease Information
| Disease | Pancreatic ductal adenocarcinoma |
|---|---|
| Lineage | Pancreas |
| Subtype | Pancreatic Adenocarcinoma |
| OncoTree Code | PAAD |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-002039_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln167Ter (c.499C>T) | Homozygous | - | Unknown |
| MutationSimple | KRAS | p.Gly12Arg (c.34G>C) | Unspecified | - | PubMed=26124327 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
11
D16S539
9,10
D18S51
13
D21S11
31
D3S1358
16
D5S818
13
D7S820
9,12
D8S1179
13,15
FGA
23
Penta D
9
Penta E
13,15
TH01
7
TPOX
8,11
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.
Mendell J.T.
Cancer Biol. Ther. 8:2013-2024(2009).
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Kern S.E.
Cancer Res. 66:7920-7928(2006).
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.
Oncol. Rep. 8:89-92(2001).