MDA-PCa-2bHomo sapiens (Human)Cancer cell line

Also known as: M.D. Anderson-Prostate Cancer-2b, MDA2B, MDAPC2B, MDAPCA2B, MDAPCa2b, MDAPCa-2b, MDA PCa 2b

🤖 AI SummaryBased on 7 publications

Quick Overview

Human prostate cancer cell line with androgen-sensitive properties.

Detailed Summary

MDA-PCa-2b is a human prostate cancer cell line derived from a bone metastasis of an African-American male. It is characterized as androgen-sensitive (AS), expressing the androgen receptor (AR) and androgen-responsive genes such as PSA. This cell line is commonly used in research to study prostate cancer biology, including mechanisms of androgen signaling, tumor progression, and drug response. Its androgen-sensitive nature makes it a valuable model for understanding the molecular pathways involved in prostate cancer development and for testing therapeutic strategies targeting androgen receptors. The cell line has been utilized in studies related to genetic ancestry, highlighting its importance in addressing health disparities in prostate cancer research.

Research Applications

Androgen signaling studiesProstate cancer biologyDrug response testingGenetic ancestry research

Key Characteristics

Androgen-sensitiveExpresses androgen receptor (AR)Derived from bone metastasisUsed in health disparities research

Generated on 6/21/2025

Basic Information

Database ID	CVCL_4748
Species	Homo sapiens (Human)
Tissue Source	Bone[UBERON:UBERON_0002481]

Donor Information

Age	63
Age Category	Adult
Sex	Male
Race	black_or_african_american

Disease Information

Disease	Prostate carcinoma
Lineage	Prostate
Subtype	Prostate Adenocarcinoma
OncoTree Code	PRAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000952_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

11,12

D16S539

10,11

D18S51

16,17

D19S433

13.2,14.2,16

D21S11

33.2

D2S1338

22,24

D3S1358

14,17

D5S818

12,13

D7S820

8,10

D8S1179

14,15

FGA

20,21,22

Penta D

11,13

Penta E

8,14

TH01

8,9

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.

Mitra R., Nonn L., Kimbro K.S., Kittles R.A.

Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019).

DOI PubMed PMC

A novel approach for characterizing microsatellite instability in cancer cells.

Lu Y.-H., Soong T.D., Elemento O.

PLoS ONE 8:E63056-E63056(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.

Brooks J.D.

Prostate 63:187-197(2005).

DOI PubMed

Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.

Nordeen S.K., Miller G.J., Varella-Garcia M.

Prostate 57:226-244(2003).

DOI PubMed

Molecular characterization of human prostate carcinoma cell lines.";

Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.

Prostate 57:205-225(2003).

DOI PubMed

Human prostate cancer cell lines.";

Russell P.J., Kingsley E.A.

Methods Mol. Med. 81:21-39(2003).

DOI PubMed

Establishment of two human prostate cancer cell lines derived from a single bone metastasis.

Logothetis C.J.

Clin. Cancer Res. 3:2493-2500(1997).

PubMed