Z-33Homo sapiens (Human)Cancer cell line
Also known as: Z33
🤖 AI SummaryBased on 2 publications
Quick Overview
Z-33 is a human cell line derived from leukemia, used in research on BCR-ABL fusion genes and leukemogenesis.
Detailed Summary
Z-33 is a human leukemia cell line that has been studied for its expression of BCR-ABL fusion genes. Research indicates that Z-33 expresses the ABL1b-BCR splice variant, which is associated with the m-bcr translocation. The cell line is part of a panel of BCR-ABL-positive cell lines used to investigate the molecular mechanisms of leukemogenesis. Z-33 does not express normal BCR transcripts, which is consistent with the presence of m-bcr translocations. The cell line's characteristics make it a valuable tool for studying the role of reciprocal fusion genes in leukemia development.
Research Applications
BCR-ABL fusion gene analysisLeukemogenesis researchReciprocal fusion gene expression
Key Characteristics
ABL1b-BCR splice variant expressionm-bcr translocationNo normal BCR transcript expression
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4796 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Disease Information
| Disease | B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | ABL1 | BCR-ABL1, BCR-ABL | - | BCR exon 1 fused to ABL1 exon 2 | PubMed=10576511, PubMed=10071072, PubMed=8751477 |
Publications
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
Leuk. Res. 23:1055-1060(1999).
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leuk. Res. 23:207-215(1999).
Molecular and biologic characterization of a newly established Philadelphia-positive acute lymphoblastic leukemia cell line (Z-33) with an autocrine response to GM-CSF.
Hirsch-Ginsberg C.F., Huh Y.O., Yee G., Kurzrock R.
Leukemia 10:1534-1543(1996).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).