PK-59Homo sapiens (Human)Cancer cell line

Also known as: PK59

🤖 AI SummaryBased on 8 publications

Quick Overview

Human pancreatic cancer cell line with metabolic and drug resistance characteristics.

Detailed Summary

PK-59 is a human pancreatic cancer cell line derived from pancreatic ductal adenocarcinoma (PDAC). It exhibits distinct metabolic characteristics, including a glycolytic and lipogenic metabolic subtype, which influences its response to metabolic inhibitors. Research indicates that PK-59 shows sensitivity to certain metabolic drugs, such as those targeting glycolysis and lipid synthesis, but resistance to others. Additionally, PK-59 has been associated with gemcitabine resistance due to inactivation of deoxycytidine kinase (DCK), a key enzyme in drug activation. These properties make PK-59 a valuable model for studying pancreatic cancer metabolism, drug resistance mechanisms, and therapeutic strategies.

Research Applications

Metabolic profiling and drug sensitivityDrug resistance mechanisms (e.g., gemcitabine resistance)Metabolic subtype analysis (glycolytic/lipogenic)Gene expression and mutation analysis

Key Characteristics

Glycolytic and lipogenic metabolic subtypeResistance to gemcitabine due to DCK inactivationSensitivity to metabolic inhibitors targeting glycolysis and lipid synthesis

Generated on 6/21/2025

Basic Information

Database ID	CVCL_4897
Species	Homo sapiens (Human)
Tissue Source	Liver[UBERON:UBERON_0002107]

Donor Information

Age	66
Age Category	Adult
Sex	Female

Disease Information

Disease	Pancreatic carcinoma
Lineage	Pancreas
Subtype	Pancreatic Adenocarcinoma
OncoTree Code	PAAD

DepMap Information

Source Type	JCRB
Source ID	ACH-000205_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

10,12

D16S539

11,12

D18S51

D21S11

30,31

D3S1358

D5S818

D7S820

D8S1179

FGA

Penta D

8,11

Penta E

16,22

TH01

8,9

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.

Ishida M., Motoi F., Egawa S., Unno M., Horii A.

Biochem. Biophys. Res. Commun. 421:98-104(2012).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.

Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.

Oncol. Rep. 8:89-92(2001).

DOI PubMed

The time of occurrence of liver metastasis in carcinoma of the pancreas.

Amikura K., Kobari M., Matsuno S.

Int. J. Pancreatol. 17:139-146(1995).

DOI PubMed