MS751Homo sapiens (Human)Cancer cell line

Also known as: MS 751, MS-751

🤖 AI SummaryBased on 7 publications

Quick Overview

MS751 is a human cervical cancer cell line with HPV46 infection and SMAD4 deficiency.

Detailed Summary

MS751 is a human cervical cancer cell line derived from squamous cell carcinoma. It is characterized by the presence of HPV46 and a deficiency in the SMAD4 gene, which is involved in the TGF-β signaling pathway. This cell line has been used in studies investigating the molecular mechanisms of cervical carcinogenesis and the role of SMAD4 in tumor progression. Research on MS751 has contributed to understanding the genetic alterations associated with cervical cancer, including the loss of SMAD4 expression and its implications in cancer development and treatment response.

Research Applications

Cervical Cancer ResearchSMAD4 Deficiency StudiesHPV46 Infection Analysis

Key Characteristics

HPV46 PositiveSMAD4 DeficientCervical Squamous Cell Carcinoma
Generated on 6/21/2025

Basic Information

Database IDCVCL_4996
SpeciesHomo sapiens (Human)
Tissue SourceLymph node[UBERON:UBERON_0000029]

Donor Information

Age47
Age CategoryAdult
SexFemale

Disease Information

DiseaseSquamous cell carcinoma of the cervix uteri
LineageCervix
SubtypeCervical Squamous Cell Carcinoma
OncoTree CodeCESC

DepMap Information

Source TypeATCC
Source IDACH-001360_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11
D13S317
12
D16S539
11
D18S51
12
D19S433
16
D21S11
29,30
D2S1338
22
D3S1358
19
D5S818
12
D7S820
9,11
D8S1179
14
FGA
20
Penta D
9
Penta E
12
TH01
6
TPOX
8
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.

Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.

Oncotarget 8:86369-86383(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Individual karyotypes at the origins of cervical carcinomas.";

Duesberg P.H.

Mol. Cytogenet. 6:44.1-44.23(2013).

Smad4 deficiency in cervical carcinoma cells.";

Schwarte-Waldhoff I.

Oncogene 24:810-819(2005).

Detection and characterization of human papillomavirus type 45 DNA in the cervical carcinoma cell line MS751.

Geisbill J., Osmers U., Durst M.

J. Gen. Virol. 78:655-658(1997).

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.

Rousset M., Zweibaum A., Fogh J.

Cancer Res. 41:1165-1170(1981).

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.

Am. J. Pathol. 119:361-366(1985).

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).