VMM917Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 1 publications
Quick Overview
Human melanoma cell line with autocrine IGF-1R signaling.
Detailed Summary
VMM917 is a human melanoma cell line derived from metastatic tumors. Research indicates that it exhibits autocrine signaling through the IGF-1R pathway, which plays a role in cell proliferation and survival. The cell line was used in studies to analyze receptor tyrosine kinase activation, identifying IGF-1R as a key component in melanoma progression. Inhibition of IGF-1R signaling significantly reduced melanoma cell proliferation, suggesting its potential as a therapeutic target. Additionally, the cell line was part of a comprehensive analysis of RTKs in melanomas, highlighting its relevance in understanding autocrine signaling mechanisms in cancer.
Research Applications
Analysis of autocrine signaling pathways in melanomaInvestigation of IGF-1R receptor activation and its role in cell proliferationStudy of receptor tyrosine kinase (RTK) activation in metastatic melanomas
Key Characteristics
Expresses IGF-1R and other RTKs involved in autocrine signalingDemonstrates sensitivity to IGF-1R inhibition, leading to reduced proliferationUsed in studies to identify autocrine growth factors in melanoma
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4D09 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Right posterior thigh adjacent to buttocks, hypodermis[UBERON:UBERON_0002072] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-003105_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
13
D13S317
11
D16S539
12
D5S818
11
D7S820
8,10
TH01
7,9.3
TPOX
8,11
vWA
18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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