MP41Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 1 publications
Quick Overview
Human uveal melanoma cell line for cancer research.
Detailed Summary
MP41 is a human uveal melanoma cell line established from patient-derived xenografts (PDXs). It exhibits a predominant epithelioid morphology and has been characterized for genetic alterations relevant to uveal melanoma. The cell line shows activation of the mTOR signaling pathway and is sensitive to the mTOR inhibitor Everolimus, demonstrating reduced cell viability and tumor growth inhibition in vivo. MP41 is used in preclinical studies to evaluate therapeutic targets and drug efficacy in uveal melanoma.
Research Applications
Cancer researchDrug screeningPreclinical testing
Key Characteristics
Epithelioid morphologymTOR pathway activationEverolimus sensitivity
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4D12 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Eye, uvea[UBERON:UBERON_0001768] |
Donor Information
| Age | 49 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Uveal melanoma |
|---|---|
| Lineage | Eye |
| Subtype | Uveal Melanoma |
| OncoTree Code | UM |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-002010_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | GNA11 | p.Gln209Leu (c.626A>T) | Unspecified | - | PubMed=22236444 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
9,10
D13S317
11,14
D16S539
13
D21S11
30.2,31.2
D5S818
10,13
D7S820
8.3,9,9.3,10,10.1,11
TH01
6,7
TPOX
8,11
vWA
15,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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