MP46Homo sapiens (Human)Cancer cell line

MP46 is a human uveal melanoma cell line established from patient-derived xenografts. It exhibits BAP1 mutations and loss of BAP1 protein expression, which are associated with aggressive disease. The cell line shows activation of the mTOR signaling pathway, making it a valuable model for studying mTOR-targeted therapies. MP46 has been used in preclinical studies to evaluate the efficacy of Everolimus, an mTOR inhibitor, in inhibiting cell proliferation and tumor growth. These findings highlight MP46 as a relevant model for uveal melanoma research and drug development.