MM28Homo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 1 publications
Quick Overview
Cell line for uveal melanoma research with mTOR pathway activation.
Detailed Summary
MM28 is a cell line derived from uveal melanoma, established to study the genetic and molecular characteristics of this aggressive ocular cancer. It exhibits activation of the mTOR signaling pathway, which is implicated in cell proliferation and survival. Research on MM28 has focused on evaluating the efficacy of mTOR inhibitors like Everolimus, demonstrating significant effects on cell viability and tumor growth in preclinical models. The cell line is part of a panel of UM cell lines that recapitulate the genetic landscape of uveal melanoma, providing a valuable tool for drug development and therapeutic strategy testing.
Research Applications
Uveal melanoma researchmTOR pathway studiesDrug efficacy testing
Key Characteristics
Activation of mTOR pathwaySensitivity to EverolimusGenetic alterations consistent with uveal melanoma
Generated on 6/21/2025
Basic Information
| Database ID | CVCL_4D15 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 72 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Uveal melanoma |
|---|---|
| Lineage | Eye |
| Subtype | Uveal Melanoma |
| OncoTree Code | UM |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-002013_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | GNA11 | p.Gln209Leu (c.626A>T) | Unspecified | - | PubMed=22236444 |
| MutationSimple | BAP1 | p.Tyr627Ter (c.1881C>A) | Unspecified | - | PubMed=24994677 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
8,11
D16S539
10,12
D21S11
28,29
D5S818
11
D7S820
8,10
TH01
7,9.3
TPOX
11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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