SNU-245Homo sapiens (Human)Cancer cell line

Also known as: NCI-SNU-245, SNU245

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_5038
SpeciesHomo sapiens (Human)
Tissue SourceBile duct[UBERON:UBERON_0002394]

Donor Information

Age CategoryUnknown
SexUnknown

Disease Information

DiseaseCholangiocarcinoma
LineageBiliary Tract
SubtypeExtrahepatic Cholangiocarcinoma
OncoTree CodeEHCH

DepMap Information

Source TypeKCLB
Source IDACH-000268_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg175His (c.524G>A)UnspecifiedSomatic mutation acquired during proliferationfrom parent cell line YCC-3

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11
D13S317
9,13
D16S539
9,13
D18S51
16
D19S433
14,15.2
D21S11
27,30
D2S1338
18,19
D3S1358
17,19
D5S818
7
D7S820
8,10
D8S1179
13,15
FGA
21.2,24
TH01
9.3
TPOX
8,11
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.

Vazquez F., Getz G., Bardeesy N.M.

bioRxiv 2024:07.04.601970-07.04.601970(2024).

Development and characterization of human primary cholangiocarcinoma cell lines.

Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.

Am. J. Pathol. 192:1200-1217(2022).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.

Bardeesy N.M.

Cancer Discov. 6:727-739(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

Establishment and characterisation of six human biliary tract cancer cell lines.

Kim S.-W., Park Y.-H., Hwang J.-H., Yoon Y.-B., Park J.-G.

Br. J. Cancer 87:187-193(2002).