SNU-668Homo sapiens (Human)Cancer cell line
Also known as: NCI-SNU-668, SNU668
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5081 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Donor Information
| Age | 63 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Gastric signet ring cell adenocarcinoma |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Diffuse Type Stomach Adenocarcinoma |
| OncoTree Code | DSTAD |
DepMap Information
| Source Type | KCLB |
|---|---|
| Source ID | ACH-000344_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Ser215Asn (c.644G>A) | Homozygous | - | from parent cell line SNU-668 |
| MutationSimple | KRAS | p.Gln61Lys (c.181C>A) | Homozygous | - | from parent cell line SNU-668 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
TDP1 and TOP1 modulation in olaparib-resistant cancer determines the efficacy of subsequent chemotherapy.
Kim T.-Y., Lee K.W., Oh D.-Y., Kim J.-H., Bang Y.-J.
Cancers (Basel) 12:334.1-334.17(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
Kragh M., Horak I.D., Chung H.C., Rha S.Y.
Int. J. Cancer 143:151-159(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Firestein R., Zhang Z.-M.
Nat. Commun. 5:3830.1-3830.8(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Okanoue T., Inazawa J.
Cancer Sci. 96:100-110(2005).
Characterization of chromosomal aberrations in human gastric carcinoma cell lines using chromosome painting.
Chun Y.-H., Kil J.-I., Suh Y.-S., Kim S.-H., Kim H., Park S.-H.
Cancer Genet. Cytogenet. 119:18-25(2000).