SNU-739Homo sapiens (Human)Cancer cell line
Also known as: SNU739
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5088 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 52 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Adult hepatocellular carcinoma |
|---|---|
| Lineage | Liver |
| Subtype | Hepatocellular Carcinoma |
| OncoTree Code | HCC |
DepMap Information
| Source Type | KCLB |
|---|---|
| Source ID | ACH-002523_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Ser215Arg (c.645T>G) | Homozygous | - | PubMed=30987403 |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| MutationSimple | BRCA2 | p.Arg3384Ter (c.10150C>T) | Homozygous | - | Unknown |
| MutationSimple | ARID1B | p.Gln149Serfs*83 (c.444dupT) | Unspecified | - | PubMed=31378681 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
8
D16S539
9,12
D3S1358
15,17
D5S818
11,12
D7S820
9,11
FGA
24
TH01
7,9
TPOX
8,9
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
A pharmacogenomic landscape in human liver cancers.";
Hui L.-J.
Cancer Cell 36:179-193.e11(2019).
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Gastroenterology 157:760-776(2019).
Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA.
Lee J.-H., Ku J.-L., Park Y.-J., Lee K.-U., Kim W.-H., Park J.-G.
World J. Gastroenterol. 5:289-295(1999).