SNU-81Homo sapiens (Human)Cancer cell line
Also known as: NCI-SNU-81, SNU81
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5098 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Colon[UBERON:UBERON_0001155] |
Donor Information
| Age | 53 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Colon adenocarcinoma |
|---|---|
| Lineage | Bowel |
| Subtype | Colon Adenocarcinoma |
| OncoTree Code | COAD |
DepMap Information
| Source Type | KCLB |
|---|---|
| Source ID | ACH-000991_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg213Ter (c.637C>T) | Unspecified | - | Unknown |
| MutationSimple | TP53 | p.Lys132Thr (c.395A>C) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | TBX3 | c.942-1G>T | Heterozygous | Splice acceptor mutation | Unknown, Unknown |
| MutationSimple | TBX3 | p.Glu111Ter (c.331G>T) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | PTEN | p.Glu299Ter (c.895G>T) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | PTEN | p.Arg130Gln (c.389G>A) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | KRAS | p.Ala146Thr (c.436G>A) | Unspecified | In 50% of the reads | PubMed=27004849 |
| MutationSimple | FBXW7 | p.Arg479Gln (c.1436G>A) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | APC | p.Arg2204Ter (c.6610C>T) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | APC | p.Arg1450Ter (c.4348C>T) | Unspecified | - | PubMed=24755471 |
| MutationSimple | APC | p.Ser1392Ter (c.4175C>A) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Genomic determinants of protein abundance variation in colorectal cancer cells.
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Cell Rep. 20:2201-2214(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
Nat. Commun. 6:7002.1-7002.10(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.
Eur. J. Cancer 35:1724-1729(1999).