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SNU-C4Homo sapiens (Human)Cancer cell line

Also known as: C4, NCI-SNU-C4, SNUC4, SNU C4, SNU-4c (Occasionally.)

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database ID	CVCL_5111
Species	Homo sapiens (Human)

Donor Information

Age	35
Age Category	Adult
Sex	Male
Race	asian
Subtype Features	MSI

Disease Information

Disease	Colon adenocarcinoma
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	KCLB
Source ID	ACH-000959_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly245Ser (c.733G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=28445466
MutationSimple	TGFBR2	p.Lys128Serfs*35 (c.383delA)	Homozygous	-	PubMed=12615714
MutationSimple	PTEN	p.Glu288fs*3 (c.863delA)	Heterozygous	-	Unknown
MutationSimple	MSH6	p.Phe1088Serfs*2 (c.3261delC)	Homozygous	-	from parent cell line Jurkat

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10

D13S317

8,9

D16S539

9,10

D21S11

28,30

D3S1358

16,20

D5S818

8,9

D7S820

7.3,11,12

FGA

20,21

TH01

7,8

TPOX

11

vWA

14,15

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Mariadason J.M., Sieber O.M.

Cancer Res. 74:3238-3247(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.

Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.

Eur. J. Cancer 35:1724-1729(1999).

Biology of colorectal and gastric cancer cell lines.";

Park J.-G., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:131-141(1996).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

p53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248trp) on separate alleles.

Karnes W.E. Jr.

Cancer Lett. 98:183-191(1996).

Characteristics of cell lines established from human colorectal carcinoma.

Johnson B.E., Gazdar A.F.

Cancer Res. 47:6710-6718(1987).