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SNU-C5Homo sapiens (Human)Cancer cell line

Also known as: SNU-C5/WT, NCI-SNU-C5, SNUC5

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database ID	CVCL_5112
Species	Homo sapiens (Human)
Tissue Source	Cecum[UBERON:UBERON_0001153]

Donor Information

Age	77
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Cecum adenocarcinoma
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	KCLB
Source ID	ACH-000970_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Trp (c.742C>T)	Homozygous	Somatic mutation acquired during proliferation	from parent cell line VCaP
MutationSimple	TP53	p.Val218Leu (c.652G>T)	Heterozygous	-	from parent cell line SNU-C5
MutationSimple	PIK3CA	p.His1047Arg (c.3140A>G)	Unspecified	-	PubMed=25926053, PubMed=20570890
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

11,13

D13S317

8

D16S539

8,13

D21S11

29,31.2

D3S1358

15

D5S818

11,12

D7S820

12

FGA

19,23

TH01

6,9

TPOX

8

vWA

15

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

Biology of colorectal and gastric cancer cell lines.";

Park J.-G., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:131-141(1996).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

p53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248trp) on separate alleles.

Karnes W.E. Jr.

Cancer Lett. 98:183-191(1996).

Characteristics of cell lines established from human colorectal carcinoma.

Johnson B.E., Gazdar A.F.

Cancer Res. 47:6710-6718(1987).