ACC-MESO-1Homo sapiens (Human)Cancer cell line
Also known as: MESO-1, ACCMESO1, ACC-Meso-1
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5113 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung, pleura[UBERON:UBERON_0000977] |
Donor Information
| Additional Information |
|
|---|---|
| Age | 61 |
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Pleural mesothelioma |
|---|---|
| Lineage | Pleura |
| Subtype | Pleural Mesothelioma, Epithelioid Type |
| OncoTree Code | PLEMESO |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000086_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NF2 | p.Gln389Ter (c.1165C>T) | Homozygous | - | Unknown, PubMed=16630136 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
8
D16S539
12
D5S818
12
D7S820
10,12
TH01
9
TPOX
11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Kato T., Sato T., Yokoi K., Sekido Y.
Oncogene 36:5522-5531(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Yokoi K., Sekido Y.
Cancer Sci. 106:990-999(2015).
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
Asamura H., Gemma A., Yamada T.
J. Thorac. Oncol. 10:844-851(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
LATS2 is a tumor suppressor gene of malignant mesothelioma.";
Sekido Y.
Cancer Res. 71:873-883(2011).
Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Sekido Y.
Cancer Sci. 98:438-446(2007).