HCC1195Homo sapiens (Human)Cancer cell line

Also known as: Hamon Cancer Center 1195, HCC-1195

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_5127
SpeciesHomo sapiens (Human)
Tissue SourceLung[UBERON:UBERON_0002048]

Donor Information

Age47
Age CategoryAdult
SexMale
Raceblack_or_african_american

Disease Information

DiseaseLung adenosquamous carcinoma
LineageLung
SubtypeLung Adenosquamous Carcinoma
OncoTree CodeLUAS

DepMap Information

Source TypeKCLB
Source IDACH-000868_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Gly262_Asn263delinsProAsp (c.784_789del6insCCTGAT)Heterozygous-Unknown, PubMed=10353731
MutationSimpleNRASp.Gln61Leu (c.182A>T)Unspecified-PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
12
D13S317
12
D16S539
9
D3S1358
15,16
D5S818
13
D7S820
10,11
FGA
21
TH01
7
TPOX
8,11
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Lung cancer cell lines as tools for biomedical discovery and research.

Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.

J. Natl. Cancer Inst. 102:1310-1321(2010).

MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.

Gazdar A.F., Pertsemlidis A.

J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).

High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.

Gazdar A.F., Lam S., MacAulay C., Lam W.L.

Int. J. Cancer 118:1556-1564(2006).

Comparison of features of human lung cancer cell lines and their corresponding tumors.

Ashfaq R., Minna J.D., Gazdar A.F.

Clin. Cancer Res. 5:991-1000(1999).