HCC2429Homo sapiens (Human)Cancer cell line
Also known as: Hamon Cancer Center 2429, HCC-2429, HCC-2425 (In table of supplementary material.)
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5132 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 34 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | NUT midline carcinoma |
|---|---|
| Lineage | Lung |
| Subtype | NUT Carcinoma of the Lung |
| OncoTree Code | NUTCL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000143_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg267Gln (c.800G>A) | Heterozygous | - | Unknown |
| Gene fusion | BRD4 | BRD4-NUTM1, BRD4-NUT | - | BRD4 exon 14 fused to NUTM1 exon 2 | PubMed=29348827, PubMed=28203693, PubMed=24736545 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Posner B.A., Minna J.D., Kim H.S., White M.A.
Cell 173:864-878.e29(2018).
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.
Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.
Oncotarget 8:112313-112329(2017).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.
Janicki S.M., French C.A., You J.-X.
Cancer Res. 74:3332-3343(2014).
Lung cancer cell lines as tools for biomedical discovery and research.
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
J. Natl. Cancer Inst. 102:1310-1321(2010).
Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro.
Gazdar A.F., Minna J.D., Carbone D.P., Dang T.P.
J. Med. Genet. 42:558-564(2005).