INA-6Homo sapiens (Human)Cancer cell line
Also known as: INA6
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5209 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 80 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Multiple myeloma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Plasma Cell Myeloma |
| OncoTree Code | PCM |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000512_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln331Ter (c.991C>T) | Homozygous | - | PubMed=29970484, PubMed=15287027 |
| MutationSimple | TP53 | p.Lys132Met (c.395A>T) | Heterozygous | - | from parent cell line INA-6 |
| MutationSimple | NRAS | p.Gly12Asp (c.35G>A) | Unspecified | Somatic | Wistar |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Sirota M., Wiita A.P.
Leukemia 34:2754-2765(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Addiction to c-MYC in multiple myeloma.";
Holien T., Vatsveen T.K., Hella H., Waage A., Sundan A.
Blood 120:2450-2453(2012).
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
Baum W., Roelofs A.J., Rogers M.J., Gramatzki M.
Int. J. Cancer 126:239-246(2010).
Characterization of MYC translocations in multiple myeloma cell lines.
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008).
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Stewart A.K., Carpten J.D., Bergsagel P.L.
Cancer Cell 12:131-144(2007).
Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma.
Duerr B., Hocke G.M., Steininger H., Gebhart E., Gramatzki M.
Hematol. J. 2:42-53(2001).