C80Homo sapiens (Human)Cancer cell line

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database ID	CVCL_5249
Species	Homo sapiens (Human)
Tissue Source	Rectum[UBERON:UBERON_0001052]

Donor Information

Age	69
Age Category	Adult
Sex	Male

Disease Information

Disease	Rectal adenocarcinoma
Lineage	Bowel
Subtype	Rectal Adenocarcinoma
OncoTree Code	READ

DepMap Information

Source Type	ECACC
Source ID	ACH-001459_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gln52Ter (c.154C>T)	Unspecified	-	PubMed=16418264
MutationSimple	SMAD4	p.Asp351His (c.1051G>C)	Homozygous	-	from parent cell line Caco-2
MutationSimple	KRAS	p.Ala146Val (c.437C>T)	Unspecified	-	PubMed=20570890
MutationSimple	APC	p.Leu629Ter (c.1886T>G)	Unspecified	-	PubMed=24755471

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

8,11

D16S539

9,10

D18S51

D21S11

28,29

D3S1358

16,17

D5S818

11,12

D7S820

10,11

D8S1179

13,14

FGA

20,21

Penta D

12,16

Penta E

TH01

6,7

TPOX

8,12

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pharmacoproteomic characterisation of human colon and rectal cancer.

Weichert W., Knapp S., Feller S.M., Kuster B.

Mol. Syst. Biol. 13:951-951(2017).

DOI PubMed PMC

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

DOI PubMed

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Mariadason J.M., Sieber O.M.

Cancer Res. 74:3238-3247(2014).

DOI PubMed

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.

Orphanides G., French T., Wessels L.F.A.

BMC Med. Genomics 5:66.1-66.15(2012).

DOI PubMed PMC

5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.

Br. J. Cancer 103:340-346(2010).

DOI PubMed PMC

Genomic and biological characterization of exon 4 KRAS mutations in human cancer.

Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.

Cancer Res. 70:5901-5911(2010).

DOI PubMed PMC

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.

Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.

Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).

DOI PubMed PMC

Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.

Liu Y., Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).

DOI PubMed PMC

APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.

Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.

Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).

DOI PubMed PMC

Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.

Pignatelli M., Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 96:2316-2321(1999).

DOI PubMed PMC

Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.

Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).

DOI PubMed PMC