C84Homo sapiens (Human)Cancer cell line

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_5250
SpeciesHomo sapiens (Human)
Tissue SourceCecum[UBERON:UBERON_0001153]

Donor Information

Age67
Age CategoryAdult
SexMale

Disease Information

DiseaseCecum adenocarcinoma
LineageBowel
SubtypeColon Adenocarcinoma
OncoTree CodeCOAD

DepMap Information

Source TypeECACC
Source IDACH-001460_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg342Ter (c.1024C>T)Homozygous-PubMed=29970484
MutationSimpleKRASp.Gly12Ala (c.35G>C)Unspecified-PubMed=21173094
MutationSimpleB2Mp.Asp54Asn (c.160G>A)Heterozygous-Unknown, PubMed=8197130
MutationSimpleAPCp.Arg1450Ter (c.4348C>T)Unspecified-PubMed=24755471
MutationSimpleAPCp.Arg640Trp (c.1918C>T)Unspecified-Unknown, PubMed=24755471
MutationSimpleAPCp.Arg283Ter (c.847C>T)Unspecified-PubMed=33128777

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,12
D13S317
11,12
D16S539
11,13
D18S51
17
D21S11
33.2
D3S1358
15,18
D5S818
12
D7S820
11
D8S1179
13,15
FGA
19,20
Penta D
14
Penta E
7,8
TH01
7,9.3
TPOX
8,9
vWA
14,15
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pharmacoproteomic characterisation of human colon and rectal cancer.

Weichert W., Knapp S., Feller S.M., Kuster B.

Mol. Syst. Biol. 13:951-951(2017).

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Mariadason J.M., Sieber O.M.

Cancer Res. 74:3238-3247(2014).

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.

Orphanides G., French T., Wessels L.F.A.

BMC Med. Genomics 5:66.1-66.15(2012).

5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.

Br. J. Cancer 103:340-346(2010).

Genomic and biological characterization of exon 4 KRAS mutations in human cancer.

Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.

Cancer Res. 70:5901-5911(2010).

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.

Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.

Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).

Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.

Liu Y., Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).

APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.

Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.

Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).

Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.

Pignatelli M., Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 96:2316-2321(1999).

Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.

Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).

Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.

Bicknell D.C., Rowan A.J., Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 91:4751-4755(1994).