VACO 432Homo sapiens (Human)Cancer cell line
Also known as: V432, Vaco432, VaCo432, VACO432, Vaco 432
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5402 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Colon[UBERON:UBERON_0001155] |
Donor Information
| Age | 72 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Colon carcinoma |
|---|---|
| Lineage | Bowel |
| Subtype | Colon Adenocarcinoma |
| OncoTree Code | COAD |
DepMap Information
| Source Type | Horizon Discovery |
|---|---|
| Source ID | ACH-002886_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
9,10
D13S317
11,12
D16S539
11,14
D21S11
28,33.2
D5S818
9,10,15,16
D7S820
11,13
TH01
8,9.3
TPOX
7,8
vWA
14,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
Nat. Commun. 6:7002.1-7002.10(2015).
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Minna J.D.
Oncogene 20:1005-1009(2001).
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Sparks A.B., Morin P.J., Vogelstein B., Kinzler K.W.
Cancer Res. 58:1130-1134(1998).
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Markowitz S.D., Willson J.K.V., Sy M.-S.
Proc. Natl. Acad. Sci. U.S.A. 93:7832-7837(1996).
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Willson J.K.V., Veigl M.L., Sedwick W.D., Markowitz S.D.
Oncogene 10:33-37(1995).
Comparative genomic analysis of tumors: detection of DNA losses and amplification.
Gnarra J.R., Linehan W.M., Reid B.J., Wigler M.H.
Proc. Natl. Acad. Sci. U.S.A. 92:151-155(1995).