SUM1315MO2Homo sapiens (Human)Cancer cell line

Also known as: 1315M02, SUM1315, SUM 1315, SUM-1315, SUM 1315M02, SUM-1315M02, SUM1315-MO2, SUM1315M02

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_5589
SpeciesHomo sapiens (Human)
Tissue SourceSkin[UBERON:UBERON_0002097]

Donor Information

Age CategoryUnknown
SexFemale
Subtype FeaturesTNBC

Disease Information

DiseaseInvasive breast carcinoma of no special type
LineageBreast
SubtypeBreast Invasive Ductal Carcinoma
OncoTree CodeIDC

DepMap Information

Source TypeAsterand
Source IDACH-001389_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Cys135Phe (c.404G>T)Heterozygous-PubMed=22170099, PubMed=19147553, PubMed=16142320
MutationSimpleBRCA1p.Glu23Valfs*17 (c.68_69delAG) (c.66_67AG[1]) (185delAG)Unspecified-Direct_author_submission
Gene deletionCDKN2A-HomozygousPossiblePubMed=26870271

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12
D13S317
11,12
D16S539
11
D18S51
12
D21S11
28,29
D3S1358
18
D5S818
13
D7S820
8,12
D8S1179
13,15
FGA
25
Penta D
13,15
Penta E
5
TH01
9.3
TPOX
8,10
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Development and implementation of the SUM breast cancer cell line functional genomics knowledge base.

Duchinski K., Couch D., Gray J.W., Kappler C.S.

NPJ Breast Cancer 6:30.1-30.14(2020).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Modeling precision treatment of breast cancer.";

Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.

Genome Biol. 14:R110.1-R110.14(2013).

Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.

Harrell J.C., Roman E., Adamo B., Troester M.A., Perou C.M.

Breast Cancer Res. Treat. 142:237-255(2013).

miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.

Martens J.W.M.

Breast Cancer Res. 15:R33.1-R33.17(2013).

Phenotypic and molecular characterization of MCF10DCIS and SUM breast cancer cell lines.

Barnabas N., Cohen D.

Int. J. Breast Cancer 2013:872743.1-872743.16(2013).

Molecular characterisation of cell line models for triple-negative breast cancers.

Reis-Filho J.S., Tutt A.

BMC Genomics 13:619.1-619.14(2012).

Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines.

Majewski J., Foulkes W.D.

BMC Med. Genomics 4:75.1-75.13(2011).

Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer.

Chavez K.J., Garimella S.V., Lipkowitz S.

Breast Dis. 32:35-48(2010).

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.

den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.

Breast Cancer Res. Treat. 121:53-64(2010).

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.

Cancer Cell 10:515-527(2006).

Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.

Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.

Breast Cancer Res. Treat. 99:97-101(2006).

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.

van den Ouweland A.M.W., Merajver S.D., Ethier S.P., Schutte M.

Cancer Res. 66:41-45(2006).

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.

Edwards P.A.W., Caldas C.

Carcinogenesis 26:923-930(2005).

Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.

Gooden G.C., Ethier S.P., Kallioniemi A.H., Kallioniemi O.-P.

Cancer Res. 60:4519-4525(2000).

Molecular cytogenetic analysis of 11 new breast cancer cell lines.";

Kallioniemi O.-P., Ethier S.P.

Br. J. Cancer 81:1328-1334(1999).

Constitutive activation of pp125fak in newly isolated human breast cancer cell lines.

Ignatoski K.M.W., Ethier S.P.

Breast Cancer Res. Treat. 54:173-182(1999).