NB-1643Homo sapiens (Human)Cancer cell line
Also known as: NB 1643, NB1643
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5627 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Retroperitoneal space[UBERON:UBERON_0003693] |
Donor Information
| Age | 3 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Subtype Features | MYC_Amplified |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001303_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationNone reported | TP53 | - | - | - | PubMed=19787792 |
| MutationSimple | ALK | p.Arg1275Gln (c.3824G>A) | Unspecified | Germline | from parent cell line SMS-KCN |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11,13
D13S317
12
D16S539
9,12
D18S51
12,15
D19S433
13,14
D21S11
28
D2S1338
23,24
D3S1358
16,18
D5S818
11,12
D7S820
10,11
D8S1179
14,16
FGA
22,23
Penta D
10
Penta E
7,11
TH01
8,9.3
TPOX
8,11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Sci. Data 4:170033-170033(2017).
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Nat. Genet. 45:12-17(2013).
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Reynolds C.P.
Pediatr. Blood Cancer 56:239-249(2011).
Identification of ALK as a major familial neuroblastoma predisposition gene.
Maris J.M.
Nature 455:930-935(2008).
Efficacy of systemic administration of irinotecan against neuroblastoma xenografts.
Houghton J.A., Stewart C.F., Houghton P.J.
Clin. Cancer Res. 3:423-431(1997).
Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status.
Harris L.C.
Oncol. Res. 10:235-244(1998).